PRIMARY score
The PRIMARY score is a 5-category scale developed to identify clinically significant intraprostate malignancy (csPCa) on 68Ga-prostatespecific membrane antigen (PSMA) PET/CT (68Ga-PSMA PET) using a combination of anatomic site, pattern, and intensity.
Scoring System
5-level PRIMARY score incorporating intraprostatic pattern and intensity on 68Ga-PSMA PET/CT shows potential for diagnosing csPCa with high accuracy.
The recent studies confirmed that the use of pattern and intensity within a 5-level score (PRIMARY) is reproducible between readers, with an increased or equivalent diagnostic accuracy for the detection of csPCa compared with mpMRI.
Primary
The PRIMARY score was developed to optimize the diagnostic accuracy of 68Ga-PSMA PET for csPCa intraprostatically and particularly to improve specificity over an SUVmax-based reporting
method. The PRIMARY score has been incorporated into PROMISE version 2 for reporting of 68Ga-PSMA PET.
PRIMARY II
The first prospective multicentre trial to evaluate the potential of PSMA PET (PSMA) for the diagnosis of intraprostatic malignancy in men with MRI PI-RADS 2–5, found that the combination of PSMA + MRI improved sensitivity and NPV for csPCa compared with MRI alone, while identifying a further proportion of men who could safely avoid biopsy over and above an MRI triaged approach.
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